Thursday, June 03, 2004
They found that when the body switches into the starvation mode which triggers the health benefits of restriction, the protein Sirt1 (not a fun name) turns on a key component: fat mobilization for metabolism. So, the idea is that a drug could bind the Sirt1 receptor and start releasing stored fat, so people could get the benefits of a low-calorie regimen without working.
The problem is this: I'm all for having this drug, sign me up for the Phase I trial, etc., but what's it really going to do? Will the result be free lipids just wandering around the body? Will it actually up Leptin or Adiponectin? I'd really like a magic bullet so I could eat chocolate all the time and still be skinny, but I know better than to believe we'll ever see one. Oh well, here's hoping!