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Wednesday, August 25, 2004

Liver Time 

Jet lag sucks. I don't really get it anymore, having learned to trick my system into adjusting very quickly, but I used to be totally wrecked for a few days after a big trip. Possible treatments for jetlag and shift-worker fatigue are the more commercial (and far less interesting) results of research into circadian rhythms and biological clocks. Since sequencing the genome (and before that too), scientists have found a number of genes which seem to be associated with circadian cycles, but no 'masters' have yet been identified.

A series of experiments lead to identification of a transcription factor, called Rora, which seems to function as such a 'master,' controlling another key gene in the system. The release gives lots of good background on all the processes involved, so its great reading (and not too technical!). Enjoy!

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