"It is true, and thus the question of whether it is sad or happy has no meaning whatever."
Bernhard Schlink

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Thursday, August 04, 2005

Target: Quinolinic Acid 

The battle against Alzheimer's may have a new target: quinolinic acid (QUIN), a neurotoxin known to be elevated in inflammatory neurological diseases. A paper published this week indicates that the kynurenine pathway, of which QUIN is a byproduct, is also upregulated in the hippocampus of Alzheimer's patients.

Inhibition of the kynurenine pathway has already been demonstrated effective in decreasing neurotoxicity in AIDS dementia, and there is hope that new treatments using this system could be developed relatively quickly.

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