Monday, April 30, 2007
The Easy Way Out
Sick of spending all that time at the gym, and eating nothing but celery and soy protein, hoping to lose weight? Fear not, science may soon have an answer! US researchers claim that they've developed a pill that makes mice burn fat and improve muscle tone, without any exercise. The drug seems to activate PPAR-delta, which 'turns on' fat metabolism.
The drug could be useful for treating metabolic syndrome and muscular wasting disorders, but in all honesty, we all just want to eat more chocolate.
And you know what goes well with chocolate? Cherries! The good news is that tart cherries appear to have positive effects on blood pressure, cholesterol, and glucose tolerance. The study is in rats, and the doses rather impressively high, but still this could be encouraging data - and a good excuse for more cherry pie, just like you remember from when you were a kid.
You remember that, right? If you don't, there may be a pill for that too: MIT researchers have found that inhibiting HDACs could reverse memory loss associated with neurodegeneration. Which, if it works in humans, will be a GINORMOUS leap forward in treating Alzheimer's and related disorders.
Alas, there is still no pill to cure stupidity. Graham points us to a particularly stunning example of the modern trend of pathologizing everything, combined with a healthy dose of bloody moronic.
The drug could be useful for treating metabolic syndrome and muscular wasting disorders, but in all honesty, we all just want to eat more chocolate.
And you know what goes well with chocolate? Cherries! The good news is that tart cherries appear to have positive effects on blood pressure, cholesterol, and glucose tolerance. The study is in rats, and the doses rather impressively high, but still this could be encouraging data - and a good excuse for more cherry pie, just like you remember from when you were a kid.
You remember that, right? If you don't, there may be a pill for that too: MIT researchers have found that inhibiting HDACs could reverse memory loss associated with neurodegeneration. Which, if it works in humans, will be a GINORMOUS leap forward in treating Alzheimer's and related disorders.
Alas, there is still no pill to cure stupidity. Graham points us to a particularly stunning example of the modern trend of pathologizing everything, combined with a healthy dose of bloody moronic.
Labels: Alzheimers, cherries, cholesterol, diet, drugs, exercise, fat, HDAC, hunger, hypertension, memory, metabolic syndrome, metabolism, obesity, pills, PPAR-delta, stupidity
Tuesday, November 28, 2006
Is Newer Better?
Undeniably, a central dogma of our consumerist culture is that the newest is the best - rather ironically in contrast to Americans' generally overwhelming nostalgia - but science ultimately has no time for such preferences. Sure, it'd be nice if the newest drug was always the best, and comforting if we humans were the newest and best that evolution had to offer. Turns out we're not so unique, and old cures often surpass new ones.
What sets humans apart from other animals is mainly our brains. Our myelinated neurons make transmission faster, and help us perform all that hard thinking we think we're so good at. On the downside, it seems that easily disrupted myelin sheaths may be what makes us so vulnerable to neuropsychiatric disorders like Alzheimer's.
We also have spindle cells, long 'express route' neurons linking senses to visceral processing centers to reaction centers in the brain, which help us react quickly to emotional situations and stimuli. Spindle cells were long thought unique to humans and our closest great ape relatives, helping to define what makes us 'special.' Now it seems that larger cetaceans have spindle cells too - and have had them 15 million years longer than primates. A beautiful case of convergent evolution, this finding also calls further in to question the ethics of whale hunting, and could change the way we think about our interaction with whales overall.
Over the years, we've used our myelinated brains and spindle cells to change all sorts of things about our world - including years of selectively breeding crops to suit our needs. It seems, however, that our wheat breeding may have been doing more harm than good: domesticated wheat have had silenced a gene - GPC-B1 - that seems to make wheat grow faster and have better nutritional content. Researchers are working to reverse this by cross-breeding domestic and wild wheats, hoping that the result will be a much more nutritive crop, which could help alleviate hunger.
Finally, researchers looking for a new anti-inflammatory drug to replace the disgraced likes of Vioxx have turned to a rare African plant, Aframomum melegueta, used by traditional African medics, and even gorillas(!) for millennia. The plant also seems to have pretty potent anti-microbial activity, including against MRSA. The downside? It's already extremely rare, and I can't see major commercial interests being especially good for species survival.
What sets humans apart from other animals is mainly our brains. Our myelinated neurons make transmission faster, and help us perform all that hard thinking we think we're so good at. On the downside, it seems that easily disrupted myelin sheaths may be what makes us so vulnerable to neuropsychiatric disorders like Alzheimer's.
We also have spindle cells, long 'express route' neurons linking senses to visceral processing centers to reaction centers in the brain, which help us react quickly to emotional situations and stimuli. Spindle cells were long thought unique to humans and our closest great ape relatives, helping to define what makes us 'special.' Now it seems that larger cetaceans have spindle cells too - and have had them 15 million years longer than primates. A beautiful case of convergent evolution, this finding also calls further in to question the ethics of whale hunting, and could change the way we think about our interaction with whales overall.
Over the years, we've used our myelinated brains and spindle cells to change all sorts of things about our world - including years of selectively breeding crops to suit our needs. It seems, however, that our wheat breeding may have been doing more harm than good: domesticated wheat have had silenced a gene - GPC-B1 - that seems to make wheat grow faster and have better nutritional content. Researchers are working to reverse this by cross-breeding domestic and wild wheats, hoping that the result will be a much more nutritive crop, which could help alleviate hunger.
Finally, researchers looking for a new anti-inflammatory drug to replace the disgraced likes of Vioxx have turned to a rare African plant, Aframomum melegueta, used by traditional African medics, and even gorillas(!) for millennia. The plant also seems to have pretty potent anti-microbial activity, including against MRSA. The downside? It's already extremely rare, and I can't see major commercial interests being especially good for species survival.
Labels: antiinflammatory, breeding, cetaceans, crops, drugs, evolution, hunger, myelin, neuroscience, spindle cells, wheat
