Monday, May 07, 2007
Chronic
Finals are finally over (yay!), and so much has been going on that I want to catch up about. So, some highlights:
My epidemiology professor said at one point that "chronic diseases are those things that, should we live long enough, we will all enjoy." So, in honor of the discovery of a gene responsible for the increased longevity seen from calorie-restricted diets, a few bits on chronic disease.
Two groups of researchers have found (separately) that an allele appears to be responsible for as much as a 60% increase in heart disease risk. The gene, which is especially common in white people, is not determinant: you still need lifestyle and other risk factors, but having one or two copies of this gene is no good either!
Diabetic ulcers are just one of the many complications of that potentially debilitating chronic disease, whose incidence is likely to begin really skyrocketing soon, as the world's population gets older and fatter. And now, of course, we have super-bugs, which are resistant to antibiotic treatment, which can infect these ulcers and make amputation more likely. Two new treatments may be on the horizon: honey and maggots. Both have shown promise in preliminary and anecdotal studies, the former helping healing by sterilizing the area with peroxide and dehydration, the latter doing a number of (not entirely clear) things to kill even MRSA infections.
Another chronic, but more annoying than debilitating, disease is herpes. US researchers claim to have found the gene responsible for HSV's ability to 'hide' in the body, a promising discovery for future improvements in treatment.
Once you've gotten old and have managed your diabetes and heart disease risks, living in a walkable neighborhood may be another good thing to do for yourself: US researchers found that elderly men who lived in walkable neighborhoods (those with things like sidewalks, crosswalks, and nearby shops and cafes) were less likely to be depressed than those living in nonwalkable areas. I live in a dreadfully unwalkable area, and I know I think it's depressing!
Finally: too much of a good thing. Green tea's supposed to be all kinds of good for you, right? Well yes, unless you're overdoing it. Rutgers researchers found that people who take 'green tea supplements' may be at risk of liver and kidney damage. I always say, don't take as a pill that which you can get in real life...it's just never quite right.
My epidemiology professor said at one point that "chronic diseases are those things that, should we live long enough, we will all enjoy." So, in honor of the discovery of a gene responsible for the increased longevity seen from calorie-restricted diets, a few bits on chronic disease.
Two groups of researchers have found (separately) that an allele appears to be responsible for as much as a 60% increase in heart disease risk. The gene, which is especially common in white people, is not determinant: you still need lifestyle and other risk factors, but having one or two copies of this gene is no good either!
Diabetic ulcers are just one of the many complications of that potentially debilitating chronic disease, whose incidence is likely to begin really skyrocketing soon, as the world's population gets older and fatter. And now, of course, we have super-bugs, which are resistant to antibiotic treatment, which can infect these ulcers and make amputation more likely. Two new treatments may be on the horizon: honey and maggots. Both have shown promise in preliminary and anecdotal studies, the former helping healing by sterilizing the area with peroxide and dehydration, the latter doing a number of (not entirely clear) things to kill even MRSA infections.
Another chronic, but more annoying than debilitating, disease is herpes. US researchers claim to have found the gene responsible for HSV's ability to 'hide' in the body, a promising discovery for future improvements in treatment.
Once you've gotten old and have managed your diabetes and heart disease risks, living in a walkable neighborhood may be another good thing to do for yourself: US researchers found that elderly men who lived in walkable neighborhoods (those with things like sidewalks, crosswalks, and nearby shops and cafes) were less likely to be depressed than those living in nonwalkable areas. I live in a dreadfully unwalkable area, and I know I think it's depressing!
Finally: too much of a good thing. Green tea's supposed to be all kinds of good for you, right? Well yes, unless you're overdoing it. Rutgers researchers found that people who take 'green tea supplements' may be at risk of liver and kidney damage. I always say, don't take as a pill that which you can get in real life...it's just never quite right.
Labels: amputation, chronic, depression, diabetes, diet, exercise, geneitcs, green tea, healing, heart disease, herpes, honey, HSV, infection, longevity, maggots, MRSA, pills, ulcers
Monday, April 09, 2007
Expanding
We all know that being too fat is bad for you, and a UCSD study may help understand pert of why. The researchers found that human colon cancer cells have leptin receptors which, when activated, cause the cancers to grow. The more body fat you have, the more leptin you have, which could explain why obesity is such a strong risk factor for colon (and maybe other types of) cancer.
Another problem with being too fat is the likelihood of developing the beetis. Well, if you do, there may be good news: New Zealand doctors say that a man who had piglet islet cells injected into him ten years ago to help control his diabetes still has some of them alive and producing insulin in him. This result is quite promising for future xenotransplantation procedures, which could perhaps actually cure, rather than merely reduce the symptoms of, disease.
But, if taking insulin remains necessary, that drug may soon be cheaper and easier to get: a Canadian firm claims that it's gotten safflower plants to produce human insulin in their oil. If true, this would be a massive breakthrough. And yes, I understand the environmental concerns (and am very wary of corporatizing food production), but I think this is worthwhile.
Speaking of plants, it appears that an herbal remedy may be helpful in clearing urinary tract infections: Duke researchers found that high doses of forskolin (which agonizes c-AMP receptors in the bladder) seem to force E. coli out of hiding to be cleared. Now remains the question of whether this works in humans too. And of course the question of what side effects such potent c-AMP agonism might have.
Another problem with being too fat is the likelihood of developing the beetis. Well, if you do, there may be good news: New Zealand doctors say that a man who had piglet islet cells injected into him ten years ago to help control his diabetes still has some of them alive and producing insulin in him. This result is quite promising for future xenotransplantation procedures, which could perhaps actually cure, rather than merely reduce the symptoms of, disease.
But, if taking insulin remains necessary, that drug may soon be cheaper and easier to get: a Canadian firm claims that it's gotten safflower plants to produce human insulin in their oil. If true, this would be a massive breakthrough. And yes, I understand the environmental concerns (and am very wary of corporatizing food production), but I think this is worthwhile.
Speaking of plants, it appears that an herbal remedy may be helpful in clearing urinary tract infections: Duke researchers found that high doses of forskolin (which agonizes c-AMP receptors in the bladder) seem to force E. coli out of hiding to be cleared. Now remains the question of whether this works in humans too. And of course the question of what side effects such potent c-AMP agonism might have.
Labels: Beetis, bladder, bladder cancer, c-AMP, colon cancer, diabetes, GM crops, infection, insulin, leptin, obesity, UTI
